Similar efficacy of human banked milk and bovine colostrum to decrease incidence of 1 necrotizing enterocolitis in preterm piglets

نویسندگان

  • Michael L. Jensen
  • Per T. Sangild
  • Mikkel Lykke
  • Mette Schmidt
  • Mette Boye
  • Bent B. Jensen
  • Thomas Thymann
چکیده

Similar efficacy of human banked milk and bovine colostrum to decrease incidence of 1 necrotizing enterocolitis in preterm piglets 2 3 Michael L. Jensen, Per T. Sangild, Mikkel Lykke, Mette Schmidt, Mette Boye, Bent B. Jensen, 4 Thomas Thymann 5 6 7 Department of Nutrition, Exercise and Sports, Faculty of Science and Department of 8 Reproduction, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1958 9 Frederiksberg C, Denmark, National Veterinary Institute, Technical University of Denmark, DK1

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TRANSLATIONAL PHYSIOLOGY Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets

Michael L. Jensen, Per T. Sangild, Mikkel Lykke, Mette Schmidt, Mette Boye, Bent B. Jensen, and Thomas Thymann Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg C, Denmark; Department of Reproduction, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark; National Veterinary Institute, Technical Univers...

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Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets.

Preterm birth and formula feeding predispose to necrotizing enterocolitis (NEC) in infants. As mother's milk is often absent following preterm delivery, infant formula (IF) and human donor milk (HM) are frequently used as alternatives. We have previously shown that porcine and bovine colostrum (BC) provide similar NEC protection in preterm piglets relative to IF. We hypothesized that HM exerts ...

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Raw bovine milk improves gut responses to feeding relative to infant formula in preterm piglets.

For preterm neonates, the quality of the first milk is crucial for intestinal maturation and resistance to necrotizing enterocolitis (NEC). Among other factors, milk quality is determined by the stage of lactation and processing. We hypothesized that unprocessed mature bovine milk (BM; raw bovine milk) would have less bioactivity than corresponding bovine colostrum (BC) in a preterm pig model, ...

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Intestinal threonine utilization for protein and mucin synthesis is decreased in formula-fed preterm pigs.

Threonine is an essential amino acid necessary for synthesis of intestinal (glyco)proteins such as mucin MUC2 to maintain adequate gut barrier function. In premature infants, reduced barrier function may contribute to the development of necrotizing enterocolitis (NEC). Human milk protects against NEC compared with infant formula. Therefore, we hypothesized that formula feeding decreases the MUC...

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Spray Dried, Pasteurised Bovine Colostrum Protects Against Gut Dysfunction and Inflammation in Preterm Pigs.

OBJECTIVE Feeding bovine colostrum (BC) improves gut maturation and function and protects against necrotizing enterocolitis, relative to formula in newborn preterm pigs. Before BC can be used for preterm infants, it is important to test if the milk processing, required to reduce bacterial load and increase shelf life, may affect bioactivity and efficacy of a BC product. METHODS We investigate...

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تاریخ انتشار 2013